Acute generalized exanthematous pustulosis - Akutna Generalizirana Egzantematozna Pustuloza
Akutna Generalizirana Egzantematozna Pustuloza (Acute generalized exanthematous pustulosis) (AGEP) je rijetka kožna reakcija koja je u 90 % slučajeva povezana s primjenom lijekova. Akutna generalizirana egzantematozna pustuloza (acute generalized exanthematous pustulosis) karakterizira iznenadna kožna erupcija koja se pojavljuje u prosjeku pet dana nakon početka uzimanja lijeka. Ove erupcije su pustule, odnosno male bijele ili crvene erupcije kože koje sadrže zamućeni ili gnojni materijal (gnoj). Oštećenja kože obično se povlače u roku od 1‑3 dana nakon prestanka uzimanja lijeka koji izaziva napad.
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U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Raširene lezije s eritemom i pustulama pojavljuju se iznenada.
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ReferencesAcute generalized exanthematous pustulosis (AGEP) je kožna reakcija obilježena malim kvržicama ispunjenim gnojem na crvenoj podlozi kože. Obično se javlja nakon uzimanja određenih lijekova, poput antibiotika, i brzo se širi po tijelu. Nakon prestanka uzimanja uzročnog lijeka, simptomi obično nestanu u roku od dvije sedmice, ostavljajući minimalne promjene na koži. Iako su najčešće blage i ograničene na kožu, teški slučajevi mogu se svrstati među ozbiljne kožne reakcije, poput Stevens‑Johnson syndrome ili toxic epidermal necrolysis. Liječenje je prvenstveno potporno, a prognoza za potpuno izlječenje je obično odlična.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Muškarac star 76 godina došao je u Hitnu pomoć jer mu se koža promijenila u protekla dva dana. Doktori su pronašli crvene mrlje i izbočine na njegovom trupu i rukama i nogama. Kako je vrijeme odmicalo, ove mrlje su se spojile i pojavile su se kvržice nalik na bubuljice u crvenim područjima. Testovi su pokazali visok broj bijelih krvnih zrnaca s puno neutrofila i povećane razine C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
